Function and regulation of the neutrophil MEL-14 antigen in vivo: comparison with LFA-1 and MAC-1.

@article{Jutila1989FunctionAR,
  title={Function and regulation of the neutrophil MEL-14 antigen in vivo: comparison with LFA-1 and MAC-1.},
  author={Mark A. Jutila and Lusijah S. Rott and Ellen Lakey Berg and Eugene C. Butcher},
  journal={Journal of immunology},
  year={1989},
  volume={143 10},
  pages={3318-24}
}
The CD11/18 (LFA-1, Mac-1) molecules participate in neutrophil adhesion to cultured endothelium in vitro and are critical for effective neutrophil localization into inflamed tissues in vivo. More recently, the MEL-14 Ag, which was first defined as a lymphocyte homing receptor, has also been implicated in inflammatory neutrophil extravasation. Here we compare the regulation and function of these adhesion molecules on neutrophils during the in vivo inflammatory response. The MEL-14 Ag is… CONTINUE READING