Function and regulation of the Rho guanine nucleotide exchange factor Trio.

@article{Schmidt2014FunctionAR,
  title={Function and regulation of the Rho guanine nucleotide exchange factor Trio.},
  author={Susanne I. Schmidt and Anne Debant},
  journal={Small GTPases},
  year={2014},
  volume={5},
  pages={e29769}
}
Rho GTPases oscillate between an inactive GDP-bound state and an active GTP-bound state. They are activated by Rho Guanine nucleotide Exchange Factors (GEF), which accelerate the GDP to GTP exchange. RhoGEFs fall into two different classes: the Dbl family and the DOCK family of proteins. In this review, we focus on the function and regulation of the Dbl family RhoGEF Trio. Trio and its paralog Kalirin are unique within this family in that they display two GEF domains of distinct specificity… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…