Function and regulation of retinoic acid-inducible gene-I.

  title={Function and regulation of retinoic acid-inducible gene-I.},
  author={Tomoh Matsumiya and Diana M. Stafforini},
  journal={Critical reviews in immunology},
  volume={30 6},
Antiviral innate immunity is triggered by sensing viral nucleic acids. RIG-I (retinoic acid-inducible gene-I) is an intracellular molecule that responds to viral nucleic acids and activates downstream signaling, resulting in the induction of members of the type I interferon (IFN) family, which are regarded among the most important effectors of the innate immune system. Although RIG-I is expressed ubiquitously in the cytoplasm, its levels are subject to transcriptional and post-transcriptional… CONTINUE READING
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