Function and maturation of the Fe-S center in dihydroxyacid dehydratase from Arabidopsis.

@article{Gao2018FunctionAM,
  title={Function and maturation of the Fe-S center in dihydroxyacid dehydratase from Arabidopsis.},
  author={Huanyao Gao and Tamanna Azam and Sajini Randeniya and J{\'e}r{\'e}my Couturier and Nicolas Rouhier and Michael K. Johnson},
  journal={The Journal of biological chemistry},
  year={2018},
  volume={293 12},
  pages={
          4422-4433
        }
}
Dihydroxyacid dehydratase (DHAD) is the third enzyme required for branched-chain amino acid biosynthesis in bacteria, fungi, and plants. DHAD enzymes contain two distinct types of active-site Fe-S clusters. The best characterized examples are Escherichia coli DHAD, which contains an oxygen-labile [Fe4S4] cluster, and spinach DHAD, which contains an oxygen-resistant [Fe2S2] cluster. Although the Fe-S cluster is crucial for DHAD function, little is known about the cluster-coordination environment… CONTINUE READING

Citations

Publications citing this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 71 REFERENCES

Dihydroxy acid dehydratase from spinach contains a [2Fe-2S] cluster.

  • The Journal of biological chemistry
  • 1988
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL