Function and information content of DNA methylation

@article{Schbeler2015FunctionAI,
  title={Function and information content of DNA methylation},
  author={D. Sch{\"u}beler},
  journal={Nature},
  year={2015},
  volume={517},
  pages={321-326}
}
Cytosine methylation is a DNA modification generally associated with transcriptional silencing. Factors that regulate methylation have been linked to human disease, yet how they contribute to malignances remains largely unknown. Genomic maps of DNA methylation have revealed unexpected dynamics at gene regulatory regions, including active demethylation by TET proteins at binding sites for transcription factors. These observations indicate that the underlying DNA sequence largely accounts for… Expand
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