Function and factor interactions of a locus control region element in the mouse T cell receptor-alpha/Dad1 gene locus.

@article{Ortiz2001FunctionAF,
  title={Function and factor interactions of a locus control region element in the mouse T cell receptor-alpha/Dad1 gene locus.},
  author={Benjamin D. Ortiz and Faith Harrow and Dragana Cado and Buyung Santoso and Astar Winoto},
  journal={Journal of immunology},
  year={2001},
  volume={167 7},
  pages={3836-45}
}
Locus control regions (LCRs) refer to cis-acting elements composed of several DNase I hypersensitive sites, which synergize to protect transgenes from integration-site dependent effects in a tissue-specific manner. LCRs have been identified in many immunologically important gene loci, including one between the TCRdelta/TCRalpha gene segments and the ubiquitously expressed Dad1 gene. Expression of a transgene under the control of all the LCR elements is T cell specific. However, a subfragment of… CONTINUE READING

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Benjamin Ortiz

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