Function and evolution in the NGF family and its receptors.

  title={Function and evolution in the NGF family and its receptors.},
  author={Ted Ebendal},
  journal={Journal of neuroscience research},
  volume={32 4},
  • Ted Ebendal
  • Published 1992 in Journal of neuroscience research
The gene family of neurotrophins includes nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). Recently, neurotrophin-5 (NT-5), a possible mammalian homologue to NT-4 described in the frog Xenopus, has been cloned in man and rat. The neurotrophins stimulate survival and differentiation of a range of target neurons by binding to cell surface receptors. The structure of NGF has recently been clarified from crystallographic data… CONTINUE READING


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