Function and developmental origin of a mesocortical inhibitory circuit

  title={Function and developmental origin of a mesocortical inhibitory circuit},
  author={Anna Kabanova and Milan Pabst and Markus Lorkowski and Oliver Braganza and Anne Boehlen and Negar Nikbakht and Leonie Pothmann and Ankita R. Vaswani and Ruth E. J. Musgrove and Donato A. Di Monte and Magdalena Sauvage and Heinz Beck and Sandra Blaess},
  journal={Nature Neuroscience},
Midbrain ventral tegmental neurons project to the prefrontal cortex and modulate cognitive functions. Using viral tracing, optogenetics and electrophysiology, we found that mesocortical neurons in the mouse ventrotegmental area provide fast glutamatergic excitation of GABAergic interneurons in the prefrontal cortex and inhibit prefrontal cortical pyramidal neurons in a robust and reliable manner. These mesocortical neurons were derived from a subset of dopaminergic progenitors, which were… CONTINUE READING
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Genetic control of midbrain dopaminergic neuron development

  • S. Blaess, Ang, S.-L
  • Wiley Interdiscip. Rev. Dev. Biol
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