Function and Regulation of Mammalian Pyruvate Dehydrogenase Complex

Abstract

We have presented evidence that stimulation of pyruvate dehydrogenase, (PDH.) kinase activity by pyruvate or by acetyl-CoA is mediated through acetylation of lipoyl moieties (Cate, R. L., and Roche, T. E. (1978) J. Biol. Chem. 253,496-503). In accord with this indirect mechanism for the action of these effecters, we now find that the degree of stimulation… (More)

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@inproceedings{Cate2002FunctionAR, title={Function and Regulation of Mammalian Pyruvate Dehydrogenase Complex}, author={Richard L. Cate and Thomas E. Roche}, year={2002} }