Function and Regulation of Heterotrimeric G Proteins during Chemotaxis

@inproceedings{Kamp2016FunctionAR,
  title={Function and Regulation of Heterotrimeric G Proteins during Chemotaxis},
  author={Marjon E. Kamp and Youtao Liu and Arjan Kortholt and Kathleen Van Craenenbroeck},
  booktitle={International journal of molecular sciences},
  year={2016}
}
Chemotaxis, or directional movement towards an extracellular gradient of chemicals, is necessary for processes as diverse as finding nutrients, the immune response, metastasis and wound healing. Activation of G-protein coupled receptors (GPCRs) is at the very base of the chemotactic signaling pathway. Chemotaxis starts with binding of the chemoattractant to GPCRs at the cell-surface, which finally leads to major changes in the cytoskeleton and directional cell movement towards the… CONTINUE READING
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