Function and Dynamics of Tetraspanins during Antigen Recognition and Immunological Synapse Formation

@article{RochaPerugini2015FunctionAD,
  title={Function and Dynamics of Tetraspanins during Antigen Recognition and Immunological Synapse Formation},
  author={Vera Rocha-Perugini and Francisco S{\'a}nchez-Madrid and Gloria Mart{\'i}nez del Hoyo},
  journal={Frontiers in immunology},
  year={2015},
  volume={6},
  pages={
          653
        }
}
Tetraspanin-enriched microdomains (TEMs) are specialized membrane platforms driven by protein-protein interactions that integrate membrane receptors and adhesion molecules. Tetraspanins participate in antigen recognition and presentation by antigen--presenting cells (APCs) through the organization of pattern-recognition receptors (PRRs) and their downstream-induced signaling, as well as the regulation of MHC-II-peptide trafficking. T lymphocyte activation is triggered upon specific recognition… CONTINUE READING
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