Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms.

  title={Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms.},
  author={Udo C. T. Oppermann and Bengt Persson and Hans J{\"o}rnvall},
  journal={European journal of biochemistry},
  volume={249 2},
Enzymatic interconversion of active and inactive glucocorticoid hormone is important, and is carried out physiologically by 11beta-hydroxysteroid dehydrogenase (11beta-HSD) isoforms, explaining their role in cellular and toxicological processes. Two forms of the enzyme, 11beta-HSD-1 and 11beta-HSD-2, belonging to the protein superfamily of short-chain dehydrogenases/reductases, have been structurally and functionally characterised. Although displaying dehydrogenase and reductase activities in… CONTINUE READING


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