Funalenone, a novel collagenase inhibitor produced by Aspergillus niger.

@article{Inokoshi1999FunalenoneAN,
  title={Funalenone, a novel collagenase inhibitor produced by Aspergillus niger.},
  author={Junji Inokoshi and Kazuro Shiomi and Rokuro Masuma and Hiromichi Tanaka and Hideaki Yamada and Satoshi O̅mura},
  journal={The Journal of antibiotics},
  year={1999},
  volume={52 12},
  pages={1095-100}
}
Funalenone, a phenalene compound that inhibits type I collagenase (MMP-1), was isolated from mycelium of Aspergillus niger FO-5904 by solvent extaction, ODS column chromatography, Sephadex LH-20 column chromatography and reversed phase HPLC. Funalenone inhibited 50% of type I collagenase activity at a concentration of 170 microM, but inhibited 18.3% and 38.7% against 72 kDa and 92 kDa type IV collagenase, respectively, at a concentration of 400 microM.