Fumonisin-induced blockade of ceramide synthase in sphingolipid biosynthetic pathway alters aortic input impedance spectrum of pigs.

  title={Fumonisin-induced blockade of ceramide synthase in sphingolipid biosynthetic pathway alters aortic input impedance spectrum of pigs.},
  author={Peter D Constable and Geoffrey William Smith and George Edwin Rottinghaus and Mike E. Tumbleson and Wanda M. Haschek},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={284 6},
The sphingolipid signaling pathway appears to play an important role in regulating vascular tone. [] Key Method Sixteen pigs were fed culture material containing fumonisin B(1) (20 mg/kg body wt) (n = 7) or a control diet (n = 9) daily for 3 days and then instrumented under alpha-chloralose anesthesia for measurement of ascending aortic pressure and flow. Fumonisin ingestion increased serum sphinganine and sphingosine concentrations. Fumonisin ingestion also decreased cardiac output and characteristic…

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