Fumaric Acid Esters Stimulate Astrocytic VEGF Expression through HIF-1α and Nrf2

  title={Fumaric Acid Esters Stimulate Astrocytic VEGF Expression through HIF-1α and Nrf2},
  author={Diana Wiesner and Irma Merdian and Jan Lewerenz and Albert Christian Ludolph and Luc Dupuis and Anke Witting},
  booktitle={PloS one},
Fumaric acid esters (FAE) are oral analogs of fumarate that have recently been shown to decrease relapse rate and disease progression in multiple sclerosis (MS), prompting to investigate their protective potential in other neurological diseases such as amyotrophic lateral sclerosis (ALS). Despite efficacy in MS, mechanisms of action of FAEs are still largely unknown. FAEs are known to activate the transcription factor Nrf2 and downstream anti-oxidant responses through the succination of Nrf2… CONTINUE READING


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