Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors

@article{Lefkove2007FumagillinAA,
  title={Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors},
  author={Benjamin Lefkove and Baskaran Govindarajan and Jack L. Arbiser},
  journal={Expert Review of Anti-infective Therapy},
  year={2007},
  volume={5},
  pages={573 - 579}
}
Fumagillin is an active amebicide and anti-infective isolated from the fungus Aspergillus fumigatus. Since its characterization in 1951, fumagillin has been studied extensively for its anti-infective properties. Although fumagillin is not approved for systemic use in the USA, this compound has one of the highest efficacies for the treatment of microsporidial infections in HIV-positive patients. Fumagillin does exhibit some side effects that have deterred its acceptance as a viable treatment… Expand
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