Fulminant hepatic failure in rats: survival and effect on blood chemistry and liver regeneration.

@article{Eguchi1996FulminantHF,
  title={Fulminant hepatic failure in rats: survival and effect on blood chemistry and liver regeneration.},
  author={Susumu Eguchi and Andreas Kamlot and Julia Y. Ljubimova and Winston R. Hewitt and Laura T. Lebow and Achilles A. Demetriou and Jacek Rozga},
  journal={Hepatology},
  year={1996},
  volume={24 6},
  pages={1452-9}
}
A reproducible experimental animal model of fulminant hepatic failure (FHF) resembling the clinical condition is needed. We have developed such a model in the rat by combining resection of the two anterior liver lobes (68% liver mass) with ligation of the right lobes pedicle (24% liver mass), resulting in liver necrosis; the remaining two omental lobes (8% liver mass) are left intact. Adult Sprague-Dawley rats (250-300 g) were used. Survival time was determined in 60 rats. Because maintenance… CONTINUE READING

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