Fulminant hepatic failure
@article{Sass2003FulminantHF, title={Fulminant hepatic failure}, author={David A. Sass and A. Obaid Shakil}, journal={Liver Transplantation}, year={2003}, volume={11} }
FHF is a devastating illness of varied causes, carrying considerable mortality and affecting patients with previously healthy livers. The clinical presentation varies widely but encephalopathy is the defining criterion. Management requires a multidisciplinary approach, including rapid triage, monitoring, and referral to a transplantation center for further evaluation. Early prognostication and timely availability of donor livers are essential for a successful outcome. A donor shortage, however…
127 Citations
AASLD PRACTICE GUIDELINES Liver Transplantation
- Medicine
These guidelines provide a data-supported approach to the treatment of patients considered for liver transplantation, intended for use by physicians, and suggest preferred approaches to the diagnostic, therapeutic, and preventative aspects of care.
Acute liver failure: current practice and recent advances.
- Medicine, BiologyGastroenterology clinics of North America
- 2011
MELD is superior to King's college and Clichy's criteria to assess prognosis in fulminant hepatic failure
- MedicineLiver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
- 2007
This study is the first to show that MELD and PELD are superior to King's College and Clichy's criteria to assess prognosis in FHF, and because data was generated from a single center and included a rather low number of patients who survived or died without OLT, further confirmation of the findings is required.
Diagnosis and manageme nt of acute liver failure
- Medicine
- 2010
Improved medical management and emergentorthotopic liver transplantation (OLT) have improved overall patient survival, yet mortality ranges from 30 to100%.
MELD score as a prognostic model for listing acute liver failure patients for liver transplantation.
- MedicineTransplantation proceedings
- 2006
References
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Fulminant hepatic failure: Summary of a workshop
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There are no specific therapies for FHF, however, liver transplantation is recommended for situations in which spontaneous recovery appears unlikely and a suitable liver graft is available for transplantation.
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Fulminant hepatic failure is the clinical syndrome associated with acute massive necrosis of liver cells. It is characterized by the sudden onset of progressive jaundice, decrease in size of the…
Early indicators of prognosis in fulminant hepatic failure.
- Medicine, BiologyGastroenterology
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Liver Transplantation for Fulminant Hepatic Failure: Experience With More Than 200 Patients Over a 17-Year Period
- MedicineAnnals of surgery
- 2003
This study demonstrates a long-term survival of nearly 70%, develops a clinically applicable and readily measurable set of pretransplant factors that determine posttransplant outcome, and demonstrates the single most important prognosticator of patient survival.
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- MedicineHepatology
- 1999
The high success rate and low donor risk may justify this option for pediatric patients, as well as for a limited population of adult patients suffering from FHF or SFHF.
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Results indicate that transjugular liver biopsy is both safe and effective as an adjuvant to the King's College criteria in the diagnosis and prognosis of patients with nonacetaminophen‐induced fulminant liver failure.
The Management of Fulminant Hepatic Failure
- Medicine
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Fulminant hepatic failure is a clinical syndrome characterized by the appearance of sudden marked impairment of liver cell function with hepatic encephalopathy, resulting from acute necrosis or dysfunction of a large portion of liver parenchyma.
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- 2002
A high transplantation rate was observed among patients listed for a highly urgent liver transplantation because of fulminant hepatic failure, and patients with paracetamol intoxication had both a higher mortality without transplantation and a higher withdrawal rate attributable to improved condition.
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We report a case of an adult female who developed fulminant hepatic failure (FHF) during the second trimester of pregnancy and underwent a successful living related liver transplantation because no…