Fulminant adenovirus hepatitis after allogeneic bone marrow transplantation.


Adenoviruses may cause severe infections in bone marrow transplant recipients. We report the case of a patient who developed fulminant hepatitis 5 months after bone marrow transplantation. Adenovirus type 2 was cultured from stool and blood samples. The patient died from liver failure. Histologic examination of post-mortem liver samples showed extensive necrosis with nuclear inclusions. Adenovirus was identified in liver cells by electron microscopy and immunohistochemical staining using a monoclonal anti-adenovirus antibody. No other pathogen was identified.


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@article{Bertheau1996FulminantAH, title={Fulminant adenovirus hepatitis after allogeneic bone marrow transplantation.}, author={Ph Bertheau and Nathalie Parquet and Françoise Ferchal and Eliane Gluckman and Claude Brocheriou}, journal={Bone marrow transplantation}, year={1996}, volume={17 2}, pages={295-8} }