Fully protected glycosylated zinc (II) phthalocyanine shows high uptake and photodynamic cytotoxicity in MCF-7 cancer cells.

@article{Kimani2013FullyPG,
  title={Fully protected glycosylated zinc (II) phthalocyanine shows high uptake and photodynamic cytotoxicity in MCF-7 cancer cells.},
  author={Stanley G Kimani and Tatiana A Shmigol and Samantha Hammond and James B Phillips and James I Bruce and Alexander J. Macrobert and Mikhail V Malakhov and Jon P Golding},
  journal={Photochemistry and photobiology},
  year={2013},
  volume={89 1},
  pages={139-49}
}
Phthalocyanine photosensitizers are effective in anticancer photodynamic therapy (PDT) but suffer from limited solubility, limited cellular uptake and limited selectivity for cancer cells. To improve these characteristics, we synthesized isopropylidene-protected and partially deprotected tetra β-glycosylated zinc (II) phthalocyanines and compared their uptake and accumulation kinetics, subcellular localization, in vitro photocytotoxicity and reactive oxygen species generation with those of… CONTINUE READING