Fully charged: Maximizing the potential of cationic polyelectrolytes in applications ranging from membranes to gene delivery through rational design

@article{Freyer2017FullyCM,
  title={Fully charged: Maximizing the potential of cationic polyelectrolytes in applications ranging from membranes to gene delivery through rational design},
  author={Jessica L. Freyer and Spencer D. Brucks and Luis M. Campos},
  journal={Journal of Polymer Science Part A},
  year={2017},
  volume={55},
  pages={3167-3174}
}
Polyelectrolytes have found utility across various applications in materials science, from electrochemical devices to biotechnology, due to their facile processing and tunable properties. Through chemistry, rational manipulation of molecular structure enables individual families of polyelectrolytes to be used in emerging advanced applications. In this perspective, we focus on cationic systems, and we describe how various structural motifs influence macromolecular properties for anion exchange… Expand
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References

SHOWING 1-10 OF 64 REFERENCES
The evolution of cyclopropenium ions into functional polyelectrolytes
TLDR
The facile synthesis of a series of polymers and nanoparticles based on monomeric cyclopropenium building blocks incorporating various functional groups that affect physical properties are demonstrated, rendering this class of new materials as an attractive alternative to develop ion-conducting membranes. Expand
Clickable Poly(ionic liquids): A Materials Platform for Transfection.
TLDR
A post-polymerization click reaction is reported that provides facile access to trisaminocyclopropenium (TAC) ion-functionalized macromolecules of various architectures, which are the first class of polyelectrolytes that bear a formal charge on carbon. Expand
Frontiers in poly(ionic liquid)s: syntheses and applications.
TLDR
Novel chemical structures, different synthetic strategies and controllable morphologies are introduced as a supplement to PIL systems already reported, and the primary properties determining applications, such as ionic conductivity, aqueous solubility, thermodynamic stability and electrochemical/chemical durability are discussed. Expand
Cationic polymers and their therapeutic potential.
TLDR
The most recent scientific advances in cationic polymers and their derivatives not only for gene delivery purposes but also for various alternative therapeutic applications are reviewed. Expand
Phosphonium cation-containing polymers: From ionic liquids to polyelectrolytes
Abstract Phosphonium cation-based ionic liquids (ILs) are a readily available family of ILs that often offer superior properties compared to ammonium cation-based ILs. Recently investigatedExpand
Enhancement of anhydrous proton transport by supramolecular nanochannels in comb polymers.
TLDR
It is reported that proton-conducting systems derived from facially amphiphilic polymers that exhibit organized supramolecular assemblies show a dramatic enhancement in anhydrous conductivity relative to analogous materials that lack the capacity for self-organization. Expand
Polyphosphonium polymers for siRNA delivery: an efficient and nontoxic alternative to polyammonium carriers.
TLDR
The present results show that the use of positively charged phosphonium groups is a worthy choice to achieve a good balance between toxicity and transfection efficiency in gene delivery systems. Expand
Polyelectrolyte vectors for gene delivery: influence of cationic polymer on biophysical properties of complexes formed with DNA.
TLDR
To achieve small, stable complexes, the use of cationic polymers with short side chains bearing primary amino groups is suggested. Expand
Influence of Substituent Chain Branching on the Transfection Efficacy of Cyclopropenium-Based Polymers
TLDR
These studies highlight the importance of exercising precise control over polymer structure, both in terms of backbone identity and substituent nature, and the necessity of a robust, modular platform from which to study them. Expand
Effect of Molecular Weight on the Ion Transport Mechanism in Polymerized Ionic Liquids
The unique properties of ionic liquids (ILs) have made them promising candidates for electrochemical applications. Polymerization of the corresponding ILs results in a new class of materials calledExpand
...
1
2
3
4
5
...