Fully automated synthesis system of 3'-deoxy-3'-[18F]fluorothymidine.

  title={Fully automated synthesis system of 3'-deoxy-3'-[18F]fluorothymidine.},
  author={Seung Jun Oh and Christoph Mosdzianowski and Dae Yoon Chi and Jung Young Kim and Se Hun Kang and Jin Ryu and J. S. Yeo and Dae Hyuk Moon},
  journal={Nuclear medicine and biology},
  volume={31 6},
We developed a new fully automated method for the synthesis of 3'-deoxy-3'-[18F]fluorothymidine ([18F]FLT), by modifying a commercial FDG synthesizer and its disposable fluid pathway. Optimal labeling condition was that 40 mg of precursor in acetonitrile (2 mL) was heated at 150 degrees C for 100 sec, followed by heating at 85 degrees C for 450 sec and hydrolysis with 1 N HCl at 105 degrees C for 300 sec. Using 3.7 GBq of [18F]F- as starting activity, [18F]FLT was obtained with a yield of 50.5… CONTINUE READING