Fully automated interpretation of ionizing radiation-induced γH2AX foci by the novel pattern recognition system AKLIDES®.

@article{Runge2012FullyAI,
  title={Fully automated interpretation of ionizing radiation-induced γH2AX foci by the novel pattern recognition system AKLIDES®.},
  author={Roswitha Runge and Rico Hiemann and Maria Wendisch and Ulla Kasten-Pisula and Katja von Storch and Klaus Z{\"o}phel and Christina N Fritz and Dirk Roggenbuck and Gerd Wunderlich and Karsten Conrad and J{\"o}rg Kotzerke},
  journal={International journal of radiation biology},
  year={2012},
  volume={88 5},
  pages={439-47}
}
PURPOSE Assessment of phosphorylated histone H2AX (γH2AX) foci as a measure for double-strand breaks (DSB) is a common technique. Since visual interpretation is time-consuming and influenced by subjective factors, we adapted the pattern recognition algorithms of autoantibodies to automated reading of γH2AX foci. MATERIALS AND METHODS DSB formation was… CONTINUE READING