Fully Continuous Flow Synthesis of 5-(Aminomethyl)-2-methylpyrimidin-4-amine: A Key Intermediate of Vitamin B1

@article{Jiang2021FullyCF,
  title={Fully Continuous Flow Synthesis of 5-(Aminomethyl)-2-methylpyrimidin-4-amine: A Key Intermediate of Vitamin B1},
  author={Meifen Jiang and Minjie Liu and Huashan Huang and Fen‐er Chen},
  journal={Organic Process Research \& Development},
  year={2021}
}

Physical and numerical characterisation of an agitated tubular reactor (ATR) for intensification of chemical processes

  • H. RiceYi. He T. Hunter
  • Chemistry
    Chemical Engineering and Processing - Process Intensification
  • 2022

Continuous-flow synthesis of N,N′-bis(2,2,6,6-tetramethyl-4-piperidinyl)-1,6-hexanediamine (DTMPA) in a Micro fixed-bed reactor

An expeditious and efficient continuous-flow process is reported for the synthesis of N,N′-bis(2,2,6,6-tetramethyl-4-piperidinyl)-1,6-hexanediamine (DTMPA). The starting material 1,6-hexanediamine

References

SHOWING 1-10 OF 11 REFERENCES

10th International Symposium on Continuous Flow Reactor Technology for Industrial Applications

The 10th International Symposium on Continuous Flow Reactor Technology for Industrial Applications was held at the Ramada Plaza Milano Hotel Conference Centre, Milan, Italy from Tuesday 13th November

Seven-Step Continuous Flow Synthesis of Linezolid Without Intermediate Purification.

Herein, the blockbuster antibacterial drug linezolid is synthesized from simple starting blocks by a convergent continuous flow sequence involving seven (7) chemical transformations. This is the

Development of Two Scalable Syntheses of 4-Amino-5-aminomethyl-2-methylpyrimidine: Key Intermediate for Vitamin B1

Two scalable processes for the synthesis of 4-amino-5-aminomethyl-2-methylpyrimidine (2) are described. In the first approach, the less expensive 2-cyanoacetamide was reacted with Vilsmeier reagent

Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products

Recently, application of the flow technologies for the preparation of fine chemicals, such as natural products or Active Pharmaceutical Ingredients (APIs), has become very popular, especially in

Continuous Manufacturing in Pharmaceutical Process Development and Manufacturing.

The pharmaceutical industry has found new applications for the use of continuous processing for the manufacture of new therapies currently in development, driven by cost reduction, decreased development cycles, access to new chemistries not practical in batch, improved safety, flexible manufacturing platforms, and improved product quality assurance.

One hundred years of vitamins-a success story of the natural sciences.

This Review highlights the key achievements in the development of industrial processes for the manufacture of eight of the 13 vitamins.

Flow chemistry syntheses of natural products.

This review highlights successes in the development and application of continuous flow chemistry methods for synthesis with an emphasis on new opportunities and technological advances.