• Corpus ID: 141620610

Fully Automated 24/7 Behavioral Screening for Mutations in Targeted Cognitive Mechanisms in the Mouse

  title={Fully Automated 24/7 Behavioral Screening for Mutations in Targeted Cognitive Mechanisms in the Mouse},
  author={Charles Randy Gallistel and Adam Philip King and Alan M Daniel and Efstathios B. Papachristos and Fuat Balcı},
Current screens for memory defects in mutant mice, such as the Morris water maze, generally proceed on the assumption that memory impairment will be manifest in an altered rate of learning. The rate of learning in mutant and wild-type strains is estimated by plotting a group average measure of performance--for example, the mean latency to find the platform--as a function of trials. A problem with this approach is that the gradual approach to asymptote seen in groupaverage plots is an artifact… 

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