Fullerene nanoparticles selectively enter oxidation-damaged cerebral microvessel endothelial cells and inhibit JNK-related apoptosis.

@article{Lao2009FullereneNS,
  title={Fullerene nanoparticles selectively enter oxidation-damaged cerebral microvessel endothelial cells and inhibit JNK-related apoptosis.},
  author={F. Y. Lao and Long Chen and Wei Li and CuiCui Ge and Ying Yan Qu and Quanmei Sun and Yuliang Zhao and Dong Han and Chunying Chen},
  journal={ACS nano},
  year={2009},
  volume={3 11},
  pages={
          3358-68
        }
}
There is a dearth in fundamental cellular-level understanding of how nanoparticles interact with the cells of the blood brain barrier (BBB), particularly under the oxidative environment. The apoptosis of cerebral microvessel endothelial cells (CMECs) induced by oxidative stress injury plays a key role in the dysfunction of BBB. By use of CMECs as an in vitro BBB model, we show for the first time that C(60)(C(COOH)(2))(2) nanoparticles can selectively enter oxidized CMECs rather than normal… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 37 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2007
VIEW 1 EXCERPT

Similar Papers

Loading similar papers…