Fullerene derivatives protect endothelial cells against NO-induced damage.

@article{Lao2009FullereneDP,
  title={Fullerene derivatives protect endothelial cells against NO-induced damage.},
  author={F. Y. Lao and Wei Li and Dong Han and Ying Yan Qu and Ying Liu and Yuliang Zhao and Chunying Chen},
  journal={Nanotechnology},
  year={2009},
  volume={20 22},
  pages={
          225103
        }
}
Functional fullerene derivatives have been demonstrated with potent antioxidation properties. Nitric oxide (NO) is a free radical that plays a part in leading to brain damage when it is accumulated to a high concentration. The possible scavenging activity of NO by the hydroxylated fullerene derivative C60(OH)22 and malonic acid derivative C60(C(COOH)2)2 was investigated using primary rat brain cerebral microvessel endothelial cells (CMECs). Results demonstrate that sodium nitroprusside (SNP… CONTINUE READING
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