Full-term pregnancy induces a specific genomic signature in the human breast.

@article{Russo2008FulltermPI,
  title={Full-term pregnancy induces a specific genomic signature in the human breast.},
  author={Jos{\'e} Russo and Gabriela Andrea Balogh and Irma H. Russo},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2008},
  volume={17 1},
  pages={51-66}
}
Breast cancer risk has traditionally been linked to nulliparity or late first full-term pregnancy, whereas young age at first childbirth, multiparity, and breast-feeding are associated with a reduced risk. Early pregnancy confers protection by inducing breast differentiation, which imprints a specific and permanent genomic signature in experimental rodent models. For testing whether the same phenomenon was detectable in the atrophic breast of postmenopausal parous women, we designed a case… CONTINUE READING

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