Full-term mouse development by abolishing Zn2+-dependent metaphase II arrest without Ca2+ release.

@article{Suzuki2010FulltermMD,
  title={Full-term mouse development by abolishing Zn2+-dependent metaphase II arrest without Ca2+ release.},
  author={Toru Suzuki and Naoko Yoshida and Emi Suzuki and Erina Okuda and Anthony C. F. Perry},
  journal={Development},
  year={2010},
  volume={137 16},
  pages={2659-69}
}
In vertebrates, a rise in intracellular free Ca(2+) (Ca(2+)(i)) levels during fertilization initiates second metaphase (mII) exit and the developmental programme. The Ca(2+) rise has long been considered to be crucial for development, but verifying this contribution would benefit from defining its role during fertilization. Here, we delineate the role of Ca(2+) release during mII exit in wild-type mouse eggs and show that it is dispensable for full-term development. Exit from mII can be induced… CONTINUE READING
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