Full repression of RNA polymerase III transcription requires interaction between two domains of its negative regulator Maf1.

@article{Gajda2010FullRO,
  title={Full repression of RNA polymerase III transcription requires interaction between two domains of its negative regulator Maf1.},
  author={Anna Gajda and Joanna Towpik and Ulrich Steuerwald and Christoph W M{\"u}ller and Olivier Lefebvre and Magdalena Boguta},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 46},
  pages={35719-27}
}
Maf1, first identified in yeast Saccharomyces cerevisiae, is a general negative regulator of RNA polymerase III (Pol III). Transcription regulation by Maf1 is important under stress conditions and during the switch between fermentation and respiration. Maf1 is composed of two domains conserved during evolution. We report here that these two domains of human Maf1 are resistant to mild proteolysis and interact together as shown by pull-down and size-exclusion chromatography and that the… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.

Eukaryot Cell 8(9), 1429-1438 by gest on Sptem er 1, 2017 hp://w w w .jb.org/ D

  • S. Boisnard, G. Lagniel, +6 authors S. Chedin
  • 2009
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…