Full reconstitution of human platelets in humanized mice after macrophage depletion.

@article{Hu2012FullRO,
  title={Full reconstitution of human platelets in humanized mice after macrophage depletion.},
  author={Zheng Hu and Yong-Guang Yang},
  journal={Blood},
  year={2012},
  volume={120 8},
  pages={1713-6}
}
Cotransplantation of human fetal thymic tissue and CD34(+) fetal liver cells in nonobese diabetic (NOD)/severe combined immunodeficiency (SCID) or NOD/SCID/γc(-/-) mice results in the development of multilineage human hematopoietic cells. In this study, we show that these humanized mice had extremely low levels of human platelets. The presence of human… CONTINUE READING