Full-length dimeric MCAK is a more efficient microtubule depolymerase than minimal domain monomeric MCAK.

Abstract

MCAK belongs to the Kinesin-13 family, whose members depolymerize microtubules rather than translocate along them. We defined the minimal functional unit of MCAK as the catalytic domain plus the class specific neck (MD-MCAK), which is consistent with previous reports. We used steady-state ATPase kinetics, microtubule depolymerization assays, and microtubule… (More)

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Cite this paper

@article{Hertzer2006FulllengthDM, title={Full-length dimeric MCAK is a more efficient microtubule depolymerase than minimal domain monomeric MCAK.}, author={Kathleen M Hertzer and Stephanie C Ems-McClung and Susan L. Kline-Smith and Thomas G Lipkin and Susan P. Gilbert and Claire E Walczak}, journal={Molecular biology of the cell}, year={2006}, volume={17 2}, pages={700-10} }