Full-length GB virus C (Hepatitis G virus) RNA transcripts are infectious in primary CD4-positive T cells.

@article{Xiang2000FulllengthGV,
  title={Full-length GB virus C (Hepatitis G virus) RNA transcripts are infectious in primary CD4-positive T cells.},
  author={Jinhua Xiang and Sabina W{\"u}nschmann and Warren N. Schmidt and Jun-bin Shao and Jack T. Stapleton},
  journal={Journal of virology},
  year={2000},
  volume={74 19},
  pages={9125-33}
}
GB virus C (GBV-C or hepatitis G virus) is a recently described flavivirus which frequently leads to chronic viremia in humans. Although GBV-C is associated with acute posttransfusion hepatitis, it is not clear if the virus is pathogenic for humans. We constructed a full-length cDNA from the plasma of a person with chronic GBV-C viremia. Peripheral blood mononuclear cells (PBMCs) transfected with full-length RNA transcripts from this GBV-C clone resulted in viral replication. This was… CONTINUE READING
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