Full-field time-resolved fluorescence tomography of small animals.

  title={Full-field time-resolved fluorescence tomography of small animals.},
  author={Vivek Venugopal and Jin Chen and Fr{\'e}d{\'e}ric Lesage and Xavier Intes},
  journal={Optics letters},
  volume={35 19},
In this experimental investigation, we explore the feasibility of using wide-field illumination for time-resolved fluorescence molecular tomography. The performance of wide-field patterns with a time-resolved imaging platform is investigated in vitro and in a small animal model. A Monte Carlo-based forward model is employed to reconstruct fluorescence yield based on time-gated datasets. An improvement in resolution and quantification when using the time-gate data type compared to the commonly… CONTINUE READING