Full dose vincristine (without 2-mg dose limit) in the treatment of lymphomas.

@article{Haim1994FullDV,
  title={Full dose vincristine (without 2-mg dose limit) in the treatment of lymphomas.},
  author={Nissim Haim and Ron Epelbaum and Menachem Ben-Shahar and David Yarnitsky and Waleed Simri and Eliezer Robinson},
  journal={Cancer},
  year={1994},
  volume={73 10},
  pages={2515-9}
}
BACKGROUND Most current lymphoma protocols limit vincristine dose to 2 mg per single dose. Because a lower dose of vincristine may be associated with poorer outcome, there is some rationale to increase the dose of vincristine. METHODS The feasibility of full dose vincristine (i.e., 1.4 mg/m2 without 2-mg dose limit) was prospectively evaluated in lymphoma patients treated with various combinations. After an initial dose of 1.4 mg/m2, patients were carefully monitored, and dose was modified… CONTINUE READING