Full characterization of GPCR monomer–dimer dynamic equilibrium by single molecule imaging

@inproceedings{Kasai2011FullCO,
  title={Full characterization of GPCR monomer–dimer dynamic equilibrium by single molecule imaging},
  author={Rinshi S. Kasai and Kenichi G. N. Suzuki and Eric R Prossnitz and Ikuko Koyama-Honda and Chieko Nakada and Takahiro K. Fujiwara and Akihiro Kusumi},
  booktitle={The Journal of cell biology},
  year={2011}
}
Receptor dimerization is important for many signaling pathways. However, the monomer-dimer equilibrium has never been fully characterized for any receptor with a 2D equilibrium constant as well as association/dissociation rate constants (termed super-quantification). Here, we determined the dynamic equilibrium for the N-formyl peptide receptor (FPR), a chemoattractant G protein-coupled receptor (GPCR), in live cells at 37°C by developing a single fluorescent-molecule imaging method. Both before… CONTINUE READING
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