Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy.

  title={Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy.},
  author={Georg M Lauer and Michaela Lucas and Joerg Timm and Kei Ouchi and Arthur Y. Kim and Cheryl L. Day and Julian Schulze zur Wiesch and Glaucia Paranhos-Baccala and Isabelle Sheridan and Deborah R Casson and Markus Reiser and Rajesh T Gandhi and Bin Li and Todd M. Allen and Raymond Tsang Chi Chung and Paul Klenerman and Bruce D. Walker},
  journal={Journal of virology},
  volume={79 20},
Multispecific CD8(+) T-cell responses are thought to be important for the control of acute hepatitis C virus (HCV) infection, but to date little information is actually available on the breadth of responses at early time points. Additionally, the influence of early therapy on these responses and their relationships to outcome are controversial. To investigate this issue, we performed comprehensive analysis of the breadth and frequencies of virus-specific CD8(+) T-cell responses on the single… CONTINUE READING


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