Full automation of (68)Ga labelling of DOTA-peptides including cation exchange prepurification.

@article{Ocak2010FullAO,
  title={Full automation of (68)Ga labelling of DOTA-peptides including cation exchange prepurification.},
  author={Meltem Ocak and Maria Antretter and Roger Knopp and Falk H-G Kunkel and Milos Petr{\'i}k and Nazan Bergişadi and Clemens Decristoforo},
  journal={Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine},
  year={2010},
  volume={68 2},
  pages={297-302}
}
Here we describe a fully automated approach for the synthesis of (68)Ga-labelled DOTA-peptides based on pre-concentration and purification of the generator eluate by using a cation exchange-cartridge and its comparison with fully automated direct labelling applying fractionated elution. Pre-concentration of the eluate on a cation exchange cartridge both using a resin-based and a disposable cation-exchange cartridge efficiently removed (68)Ge as well as major metal contaminations with Fe and Zn… CONTINUE READING

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