Full UPF3B function is critical for neuronal differentiation of neural stem cells

@inproceedings{Alrahbeni2015FullUF,
  title={Full UPF3B function is critical for neuronal differentiation of neural stem cells},
  author={Tahani Mohammed A Alrahbeni and Francesca Sartor and Jihan Anderson and Zosia H. Miedzybrodzka and Colin D. McCaig and Berndt M{\"u}ller},
  booktitle={Molecular Brain},
  year={2015}
}
Mutation in the UPF3B gene on chromosome X is implicated in neurodevelopmental disorders including X-linked intellectual disability, autism and schizophrenia. The protein UPF3B is involved in the nonsense-mediated mRNA decay pathway (NMD) that controls mRNA stability and functions in the prevention of the synthesis of truncated proteins. Here we show that NMD pathway components UPF3B and UPF1 are down-regulated during differentiation of neural stem cells into neurons. Using tethered function… CONTINUE READING
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