Fulfilling the promise: drug discovery in the post-genomic era.

@article{Chanda2003FulfillingTP,
  title={Fulfilling the promise: drug discovery in the post-genomic era.},
  author={Sumit K. Chanda and Jeremy S. Caldwell},
  journal={Drug discovery today},
  year={2003},
  volume={8 4},
  pages={
          168-74
        }
}
The genomic era has brought with it a basic change in experimentation, enabling researchers to look more comprehensively at biological systems. The sequencing of the human genome coupled with advances in automation and parallelization technologies have afforded a fundamental transformation in the drug target discovery paradigm, towards systematic whole genome and proteome analyses. In conjunction with novel proteomic techniques, genome-wide annotation of function in cellular models is possible… CONTINUE READING
BETA

Figures, Tables, and Topics from this paper.

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 48 CITATIONS

The Use of Omic Technologies Applied to Traditional Chinese Medicine Research

  • Evidence-based complementary and alternative medicine : eCAM
  • 2017
VIEW 2 EXCERPTS
CITES BACKGROUND

Activity of novel inhibitors of Staphylococcus aureus biofilms

  • Folia Microbiologica
  • 2016
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

Activation of the PKB/AKT pathway by ICAM-2

Perez, O.D
  • Immunity 16,
  • 2002

Functional organization of the yeast proteome by systematic analysis of protein complexes

Gavin, A.C
  • Nature
  • 2002

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

Y Ho
  • Nature
  • 2002

Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta-catenin signaling is activated in human colon tumors

D Yan
  • Proc. Natl. Acad. Sci. U. S. A
  • 2001

Global analysis of protein activities using proteome

H Zhu
  • chips. Science
  • 2001