Fulfilling the metabolic requirements for cell proliferation.

  title={Fulfilling the metabolic requirements for cell proliferation.},
  author={Salvador Moncada and Ernest Higgs and Sergio L Colombo},
  journal={The Biochemical journal},
  volume={446 1},
The activity of key metabolic enzymes is regulated by the ubiquitin ligases that control the function of the cyclins; therefore the activity of these ubiquitin ligases explains the coordination of cell-cycle progression with the supply of substrates necessary for cell duplication. APC/C (anaphase-promoting complex/cyclosome)-Cdh1, the ubiquitin ligase that controls G(1)- to S-phase transition by targeting specific degradation motifs in cell-cycle proteins, also regulates the glycolysis… CONTINUE READING
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