Fukuoka-1 strain of transmissible spongiform encephalopathy agent infects murine bone marrow-derived cells with features of mesenchymal stem cells.

Abstract

BACKGROUND The possible risk of iatrogenic transmissible spongiform encephalopathies (TSEs, prion diseases) from transplantation of marrow-derived mesenchymal stem cells (MSCs) is uncertain. While most cell lines resist infection, a few propagate TSE agents. STUDY DESIGN AND METHODS We generated MSC-like (MSC-L) cell cultures from bone marrow (BM) of mice… (More)
DOI: 10.1111/j.1537-2995.2010.03041.x

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