Fueling the flame: bioenergy couples metabolism and inflammation.

  title={Fueling the flame: bioenergy couples metabolism and inflammation.},
  author={Tie Fu Liu and Candice M Brown and Mohamed El Gazzar and Linda C. McPhail and Patrick Millet and Anuradha C K Rao and Vidula Vachharajani and Barbara K Yoza and Charles E McCall},
  journal={Journal of leukocyte biology},
  volume={92 3},
We review the emerging concept that changes in cellular bioenergetics concomitantly reprogram inflammatory and metabolic responses. The molecular pathways of this integrative process modify innate and adaptive immune reactions associated with inflammation, as well as influencing the physiology of adjacent tissue and organs. The initiating proinflammatory phase of inflammation is anabolic and requires glucose as the primary fuel, whereas the opposing adaptation phase is catabolic and requires… CONTINUE READING


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