Fuel metabolism in starvation.
@article{Cahill2006FuelMI, title={Fuel metabolism in starvation.}, author={George F. Cahill}, journal={Annual review of nutrition}, year={2006}, volume={26}, pages={ 1-22 } }
This article, which is partly biographical and partly scientific, summarizes a life in academic medicine. It relates my progress from benchside to bedside and then to academic and research administration, and concludes with the teaching of human biology to college undergraduates. My experience as an intern (anno 1953) treating a youngster in diabetic ketoacidosis underscored our ignorance of the controls in human fuel metabolism. Circulating free fatty acids were then unknown, insulin could not…
842 Citations
Macronutrient Metabolism in Starvation and Stress.
- BiologyNestle Nutrition Institute workshop series
- 2015
In starvation and to a lesser extent in stress starvation, the loss of protein mass is spared as much as possible and a nutritional mix containing liberal amounts of protein and carbohydrates and addition of lipids to cover energy requirements is proposed.
Starvation: Metabolic Changes
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- 2015
Glucose utilisation by the brain is decreased during prolonged starvation as the brain utilises ketone bodies as the major fuel, reducing the need for glucose.
Starvation Ketosis and the Kidney
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Ketoacidosis is a major feature of common clinical conditions to include diabetic ketoacidosis, alcoholic keto acidosis, salicylate intoxication, SGLT2 inhibitor therapy, and calorie sufficient but carbohydrate-restricted diets.
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Ketone bodies: from enemy to friend and guardian angel
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It is concluded that the increased synthesis and use of ketone bodies as ancillary fuel during periods of deficient food supply and low insulin levels causes oxidative stress in the mitochondria and that the latter initiates a protective response which allows cells to cope with increased oxidative stress and lower energy availability.
Cardiac ketone body metabolism.
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Ketone Body Metabolism Preserves Hepatic Function during Adaptation to Birth and in Overnutrition
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The methods contained here provide a relatively simple means of measuring hepatic gluconeogenesis from pyruvate using proton edited C-NMR and can easily be adapted to map the fate of various substrates.
Monocarboxylate transporter 1 deficiency and ketone utilization.
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The greater susceptibility to ketoacidosis in MCT1 deficiency with younger age may be related to the greater susceptible to ketogenesis with fasting, which correlates inversely with age.
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The βHB monoester is a salt-free βHB precursor that yields only the biologically active d-isoform of the metabolite, the pharmacokinetics of which have been studied, as has safety for human consumption in athletes and healthy volunteers and areas of uncertainty that could guide future research.
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