Fuel economy in food-deprived skeletal muscle: signaling pathways and regulatory mechanisms.

@article{Lange2007FuelEI,
  title={Fuel economy in food-deprived skeletal muscle: signaling pathways and regulatory mechanisms.},
  author={Pieter de Lange and Maria Moreno and Elena Silvestri and Assunta Lombardi and Fernando Goglia and Antonia Lanni},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2007},
  volume={21 13},
  pages={3431-41}
}
Energy deprivation poses a tremendous challenge to skeletal muscle. Glucose (ATP) depletion causes muscle fibers to undergo rapid adaptive changes toward the use of fatty acids (instead of glucose) as fuel. Physiological situations involving energy deprivation in skeletal muscle include exercise and fasting. A vast body of evidence is available on the signaling pathways that lead to structural/metabolic changes in muscle during exercise and endurance training. In contrast, only recently has a… CONTINUE READING
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