Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay mice.

@article{Hosokawa2010FucoxanthinRA,
  title={Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay mice.},
  author={Masashi Hosokawa and Tatsuya Miyashita and Sho Nishikawa and Shingo Emi and Takayuki Tsukui and Fumiaki Beppu and Tomoko N. Okada and Kazuo Miyashita},
  journal={Archives of biochemistry and biophysics},
  year={2010},
  volume={504 1},
  pages={17-25}
}
Fucoxanthin, a marine carotenoid found in edible brown seaweeds, attenuates white adipose tissue (WAT) weight gain and hyperglycemia in diabetic/obese KK-A(y) mice, although it does not affect these parameters in lean C57BL/6J mice. In perigonadal and mesenteric WATs of KK-A(y) mice fed fucoxanthin, mRNA expression levels of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-α (TNF-α), which are considered to induce insulin resistance, were markedly reduced compared to control… CONTINUE READING