Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROS-mediated Bcl-xL pathway.

@article{Kim2010FucoxanthinIA,
  title={Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROS-mediated Bcl-xL pathway.},
  author={Kil-Nam Kim and Soo-jin Heo and Sung-Myung Kang and Ginnae Ahn and You-Jin Jeon},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2010},
  volume={24 6},
  pages={1648-54}
}
Fucoxanthin, a natural biologically active substance isolated from Ishige okamurae, evidences antitumor activity in human leukemia cell HL-60 cells via the induction of apoptosis. However, the mechanism underlying fucoxanthin-induced apoptosis in HL-60 cells remains unclear. In this study, we focused on the effect of fucoxanthin induction on the accumulation of reactive oxygen species (ROS), and on the triggering of Bcl-xL signaling pathway in HL-60 cells. We determined that ROS are generated… CONTINUE READING
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