Fucose Migration in Intact Protonated Glycan Ions: A Universal Phenomenon in Mass Spectrometry.

@article{Mucha2018FucoseMI,
  title={Fucose Migration in Intact Protonated Glycan Ions: A Universal Phenomenon in Mass Spectrometry.},
  author={Eike Mucha and Maike Lettow and Mateusz Marianski and Daniel A Thomas and Weston B. Struwe and David J. Harvey and Gerard Meijer and Peter H Seeberger and Gert von Helden and Kevin Pagel},
  journal={Angewandte Chemie},
  year={2018},
  volume={57 25},
  pages={
          7440-7443
        }
}
Fucose is an essential deoxysugar that is found in a wide range of biologically relevant glycans and glycoconjugates. A recurring problem in mass spectrometric analyses of fucosylated glycans is the intramolecular migration of fucose units, which can lead to erroneous sequence assignments. This migration reaction is typically assigned to activation during collision-induced dissociation (CID) in tandem mass spectrometry (MS). In this work, we utilized cold-ion spectroscopy and show for the first… CONTINUE READING
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