Fucoidan inhibited 4T1 mouse breast cancer cell growth in vivo and in vitro via downregulation of Wnt/β-catenin signaling.

@article{Xue2013FucoidanI4,
  title={Fucoidan inhibited 4T1 mouse breast cancer cell growth in vivo and in vitro via downregulation of Wnt/β-catenin signaling.},
  author={Meilan Xue and Yin-lin Ge and Jinyu Zhang and Yongchao Liu and Qing Wang and Lin Hou and Zheng Zheng},
  journal={Nutrition and cancer},
  year={2013},
  volume={65 3},
  pages={460-8}
}
Fucoidan is a sulfated polysaccharide derived from brown algae and is known to possess anticancer properties. However, the relationship between fucoidan and β-catenin, one of the key components of the Wnt signaling pathway, in mouse breast cancer remains poorly characterized. In this study, mouse breast cancer cells (4T1) were exposed to fucoidan to investigate the relationship between fucoidan and the Wnt/β-catenin signaling pathway in vivo and in vitro. We found that fucoidan significantly… CONTINUE READING
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