Fucoidan induces apoptosis of human HS-sultan cells accompanied by activation of caspase-3 and down-regulation of ERK pathways.

@article{Aisa2005FucoidanIA,
  title={Fucoidan induces apoptosis of human HS-sultan cells accompanied by activation of caspase-3 and down-regulation of ERK pathways.},
  author={Yoshinobu Aisa and Yoshitaka Miyakawa and Tomonori Nakazato and Hideyuki Shibata and Kaori Saito and Yasuo Ikeda and Masahiro Kizaki},
  journal={American journal of hematology},
  year={2005},
  volume={78 1},
  pages={7-14}
}
Fucoidan, a sulfated polysaccharide in brown seaweed, was found to inhibit proliferation and induce apoptosis in human lymphoma HS-Sultan cell lines. Fucoidan-induced apoptosis was accompanied by the activation of caspase-3 and was partially prevented by pretreatment with a pan-caspase inhibitor, z-VAD-FMK. The mitochondrial potential in HS-Sultan cells was decreased 24 hr after treatment with fucoidan, indicating that fucoidan induced apoptosis through a mitochondrial pathway. When HS-Sultan… CONTINUE READING
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